So what's your situation now? Have you been using glycopyrrolate on and off for 15 years? Have you got a GP appointment booked? I can't imagine what reason they'd give for refusing you.
I'm in the continent over here (The Netherlands), and I'm not sure if I can get a hold on the cream here, much less on prescription. Then again as I'm not sure maybe I could... I'll have to contact my GP on the subject.
Sadly though currently my regular GP is taking a break from work and his replacement isn't really up to speed yet on HH I'm afraid.
Still, since it seems you have some experience with the glycopyrrolate cream do you think it's necessary to get the strongest solution as you mention in your post? Anything on the (side-)effects of the cream?
Did some more searching into the availability of glycopyrronium cream in The Netherlands, and surprisingly enough it turns out that someone got it prescribed by a dermatologist a view days ago (he was looking into it for a couple of weeks already, weird this simultaneous finding of the same meds, could this be a conspiracy ...or maybe he like me just read about it on this site or the esfb channel of course), in 2% solution, for primary cranial HH.
The dermatologist said that he had known about the cream already since 2002, and apparently had no objections to prescribing it.
Anyway, he (the patient) had also read that when the topical cream was applied in these small dosages, the glyco doesn't cross the blood barrier, which is good news in terms of side effects.
It's the second day and there isn't really any difference so far. But i've made an appointment to see my doctor so I can hopefully change my prescription to 2 or 3%. I think i'm wasting my time with 0.05%.
Are you still using anything else for your HH Pinker, or just the cream? Probably your doctor wants to start you on the lowest strength and then increase it until it becomes effective - especially considering the price!
I haven't used the cream but it sounds similar to the 'Secure Wipes' sold on pharmacy.ca website, they are great for forehead sweating but not so good for areas with thicker skin, like palms - the increased strength cream might work though. I hope you live in an area with a rich PCT!
After trying practically EVERY HH treatment available I have found that the best thing for me is iontophoresis for palms/feet, driclor/odaban, etc. for under my arms and Zeasorb for everywhere else! Self-prescribed oral medication worked wonderfully but the long-term side effects really troubled me, and I have very severe all-over HH so they must have bothered me a great deal for me to give-up taking them. I've discussed this on another board which I think you are also a member of Pinker.
The only downside to my current treatment protocol is that the skin on my palms is now so rough and dry that I can sand down the walls with my hands!
I use tap water iontophoresis which is fine (been using this for 2+ years), but like I say it doesn't work very well on my fingertips or the sides of my feet so i'd like something to sort that out. I used to use driclor on these areas but it doesn't seem to work anymore. It does on my underarms though. Dehydral cream doesn't really do much and I can't get that on prescription anyway.
Yep Glycopyrrolate is also in secure wipes, if you look at that the strengths they are like 1.5% - 3%. So i'm not going to get anywhere with 0.05%!! This is 20 times weaker than 1% lol. 0.05% glycopyrrolate solution used to work when I used iontophoresis, but I guess iontophoresis must be a much more effective method of transfering chemicals through the skin than simply applying a cream.
My hands have a lot of over-dry skin well. There's a lot of rough white skin on my palms, but I bet like me you'd take this over the situation before any day! Ironically my whole hands (and fingertips) are dry as i'm typing this.
Yes, it seems like 0.05 is a little underwhelming...
Like I mentioned before, someone in the Netherlands got 2% solution prescribed, and that difference is already quite big. And if they make up till 10% solutions like you said before...
Ionto was intended in the first place as an alternate way to administer drugs without having to resort to needles or oral medication (which is sometimes impossible) and to effectively administer the drug to a as small as possible area (like they do for instance with botox through ionto, they seperately treat a large number of areas). But you probably know this...
In the studies about glyco cream with the diabetic patients who suffer from gustatory sweating they are talking about 1% solution.
So, I think it's an unfortunate misunderstanding between your GP and the manufacturer.
Hi Pinker,
I left a reply for u on another thread. You asked me if I lived in the Uk. Yes, in London. I asked my GP about glycopirrolate but she said she didn't know anything about it and was not licensed to prescribe it. She referred me to a Dermatologist who Im going to see in May. I'd like to try the cream u are using and would b very interested in how you are getting on with it. I am using Odaban for my hands and feet but haven't noticed any difference yet. Will I???
I've never used odaban so I can't say. I've used driclor though, it works on my underarms but not on my hands and feet.
Your GP is right that glycopyrrolate is an un liscenced product, but thats why they just need to phone the number and speak with Andrew who is a qualified professional. Then they can arrange it for you to actually get it on prescription. Nova laborotories is one of the only places in the UK who make it (I heard there was a dermatologist in liverpool who made the cream up for a patient), but this was a while ago.
Day 3... this is wierd, I think it's actually working on the sides of my feet to some extent, but it doesn't seem to be having any effect on my fingertips still. I did an iontophoresis treatment yesterday so my fingers feel a little but dryer. I've got another GP appointment for next week.. hopefully I can change my prescription from 0.05% to something like 1% which as you say jezza they seem to use in the case reports.
Pinker, I was wondering how you got on with the glycopyrronium cream? You received a better solution yet or maybe got some results already with the 0.05 against all odds?
I'm guessing not cause it would probably be on here right now if you had.
Still, I was at the hospital this monday and I asked the nurse (my dermatologist wasn't there) about it and she told me to contact her with more information about it, so it would be good to hear the latest news on this subject and find out what's to be expected from the cream. I'd rather go on some real life data than a few clinical trials. Unfortunately the Dutch cranial HH patient from the Dutch forum hasn't reported back yet, so I'm kind of stuck here.
One more question...when you had the glyco solution for ionto, did you notice any reduction in sweating in other areas of your body except palms and feet? Unfortunately for me, the palmoplantar HH I used to have seems to have extended to the rest of my body as well over these last few years, although usually not as bad as feet and palms it's still quite bothersome in day to day life, not to mention while playing sports, so that's why I was wondering.
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...or maybe he like me just read about it on this site or the esfb channel of course), in 2% solution, for primary cranial HH.
