Even though absolute ethanol ( 95%) has been the traditional vehicle in which aluminum chloride hexahydrate has been dissolved for a great number of years, the fact remains that alcohol may cause an unbearable irritation in some patients. There are few reports that testify that alcohol gels are less irritating and better tolerated than alcohol solutions. Moreover, aluminum chloride in its alcoholic base does not penetrate adequately through the thick horny layers present on the palms and soles to exert its antiperspirant effect. The role of salicylic acid in this formulation is to enhance the penetration of aluminum chloride through the thick horny layers and, having antiperspirant properties of its own, it could act synergistically with aluminum chloride to enhance the required antiperspirant effect.
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