Topical Botox

I think this is related to a study that has been posted here in the past, but anyways:

http://www.technologypartners.com/press/Revance_Botulinumtoxinintopicalformdrawsinterest.pdf

painless botox would be wonderful.

The thing that bothers me is that the scientists are concentrating on reducing the symptoms and not curing the condition. The condition is not in the sweat glands but in the nervous system. That is where this has to be fought. I believe that people with HH has an overactive nervous system and that it is not only affecting our sweating but our blood pressure and general healt.

The condition isn't in the nervous system, it's a blood dilation problem. Which is exactly the same thing that causes flushing/blushing - and also why most HH patients happen to blush (and vice versa).

The problem with blood dilation is it's a bitch to cure. I'm about to start clonidine, once I get chance to book an appointment with my GP, as that helps with dilation to an extent.

Ok, Im sorry kingflab, I thought I knew better. It makes sense because otherwise Beta blockers would work but they dont. Could you maybe tell me a bit more about blood dilation? It seems to affect the blood pressure though as well as the nervous system...

Vasodilation refers to the widening of blood vessels[1] resulting from relaxation of smooth muscle cells within the vessel walls, particularly in the large arteries, smaller arterioles and large veins. The process is essentially the opposite of vasoconstriction, or the narrowing of blood vessels. When vessels dilate, the flow of blood is increased due to a decrease in vascular resistance. Therefore, dilation of arterial blood vessels (mainly arterioles) leads to a decrease in blood pressure. The response may be intrinsic (due to local processes in the surrounding tissue) or extrinsic (due to hormones or the nervous system). Additionally, the response may either be localized to a specific organ (depending on the metabolic needs of a particular tissue, as during strenuous exercise), or systemic (seen throughout the entire systemic circulation). Factors that result in vasodilation are termed vasodilators.

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Wikipedia

Essential hyperhidrosis, a disorder of the eccrine sweat glands, is associated with sympathetic overactivity and the aim of the present study was to determine endothelium-dependent vasodilator function in patients with this condition

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http://www.ncbi.nlm.nih.gov/pubmed/15914950

Heh. Wish I could. Doctor Roland Payne pretty much discussed the whole thing with me for about an hour. Unfortunately explain medical things in laymen's terms is something I'm not very good at.

The nervous system is certainly part of the problem, but my understand is it's blood dilation that causes the initial problem, this then causes numerous other problems like a hyperactive nervous system etc etc etc.

I'd love to try clonidine but it doesnt seem to be available in my country (Sweden). Does it go under different names or something? Can I get it through some internet pharmacy?

kingflab said:

The condition isn't in the nervous system, it's a blood dilation problem. Which is exactly the same thing that causes flushing/blushing - and also why most HH patients happen to blush (and vice versa).

The problem with blood dilation is it's a bitch to cure. I'm about to start clonidine, once I get chance to book an appointment with my GP, as that helps with dilation to an extent.

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Please keep us posted. After you come back from the doctor with a prescription for clonidine it would be great if you could start a thread and walk us through your use of it.

Yeah I'd love to hear the effect of Clonidine!!

i also too really want to try clonidine , too stuckwithme im going to buy it from edrugnet a interent pharmacy but you can look at the forum drugbuyers.com for a list of other pharmacies ,each one has feedback from other buyers.

Er guys, as far as I know clonidine doesn't stop hyperhidrosis. I mean it might do... I have no idea.. just have to wait and see. I should be getting an appointment with the GP on monday anyway.

hello king flab
wot exactly is clondine i dnt really understand ha sorry a bit of a dur dur.And i noticed u said ppl with hh has problems with blushing,yet i dnt have any problems with blushing.Also have u ever heard of a op called bretteville jensen procedure,i cant find out much about it,but ive heard its a good op to have for hh.

Right guys, I've got the clonidine perspcription. It'll take a week or two to take affect, but I'll keep you guys informed of how I get on.

-edit- Brunettee, I wouldn't worry too much, not everybody with hyperhidrosis blushes, but quite a few people do. I've never heard of the Bretteville jensen procedure, and a quick google search couldn't pull anything useful. Are you sure you spelt it right?

They said that axillary hh patients tested it in the pdf and saw good improvements. so I guess its not painful to the skin

Heh, who knows.

I'll let you know how it goes anyway.

hello king flab
i just put bretteville jenson procedure in google and there isnt alot of info on it,i thought u mite ov heard of it. I rung bupa well it isnt bupa anymore its called something else but anyway there is a a op called bretteville jenson but they dnt do it. Y is it so bloody hard tryin to get info on stuff like this. From what ive heard it cures the underarm sweating permantly as the arm pit is fully removed,they remove it by goin into the breast tissue and under the arm and cuttin the whole thing out,thats all i can find on it. I was due to have the curettage like u had in june,but ive got a letter this morning and its been cancelled for some reason as they aint doin anymore procedures like this till the end of the year,its pissed me rite off as i really wanted it done,i mite give botox another go but ive a feeling im wasteing my money. I had paid to botox done several times many years ago b4 my op on the nhs,since my sweating has come back it isnt as bad so im thinkin shud i give it another go,does botox help with odar do u know as i see this as my biggest problen now not the sweating.